The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2025
Filed:
Apr. 17, 2020
Applicant:
Sumitomo Pharma Co., Ltd., Osaka, JP;
Inventors:
Assignee:
Sumitomo Pharma Co., LTD., Osaka, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/42 (2006.01); C07B 57/00 (2006.01);
U.S. Cl.
CPC ...
C07D 211/42 (2013.01); C07B 57/00 (2013.01);
Abstract
The present invention provides a method in which when using (+)-dibenzoyl-D-tartaric acid to optically divide (±)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinone, an ether-based solvent is added and an extremely high yield of (R)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinone (+)-dibenzoyl-D-tartrate is thereby obtained, a slurry thereof is treated with a base, a 'three-dimensionally bulky reducing agent' is subsequently used, and cis-(−)-flocinopiperidol is thereby produced with surprisingly high selectivity.