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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12303898 B1

PDFFull Text
Date of Patent:
May. 20, 2025

Filed:

Jul. 15, 2019

Microfluidic devices and methods of use

Applicant:

The Governing Council of the University of Toronto, Toronto, CA;

Inventors:

Shana Olwyn Kelley, Toronto, CA;

Edward Sargent, Toronto, CA;

David Philpott, Toronto, CA;

Peter Aldridge, Toronto, CA;

Stephane Angers, Mississauga, CA;

Jason Moffat, Toronto, CA;

Barbara Mair, Toronto, CA;

Sanna Masud, Scarborough, CA;

Assignee:

The Governing Council of the University of Toronto, Toronto, CA;

Attorneys:

Smart & Biggar LP

Carmela De Luca

Primary Examiner:

Jennifer Wecker

Assistant Examiner:

Oyeleye Alexander Alabi

Int. Cl.
CPC ...
B01L 3/00 (2006.01); A47L 15/42 (2006.01); A61L 27/16 (2006.01); A61L 27/56 (2006.01); B01F 23/00 (2022.01); B01F 23/41 (2022.01); B01F 101/23 (2022.01); B01L 7/00 (2006.01); B01L 9/00 (2006.01); B03C 1/01 (2006.01); B03C 1/033 (2006.01); B03C 1/28 (2006.01); B23Q 17/24 (2006.01); C07K 14/705 (2006.01); C08F 220/56 (2006.01); C08L 33/26 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12M 3/06 (2006.01); C12N 15/10 (2006.01); C12Q 1/04 (2006.01); C12Q 1/18 (2006.01); C12Q 1/6844 (2018.01); C12Q 1/686 (2018.01); G01N 1/31 (2006.01); G01N 21/17 (2006.01); G01N 21/3577 (2014.01); G01N 21/359 (2014.01); G01N 21/39 (2006.01); G01N 21/45 (2006.01); G01N 21/64 (2006.01); G01N 21/77 (2006.01); G01N 21/78 (2006.01); G01N 27/414 (2006.01); G01N 30/12 (2006.01); G01N 30/68 (2006.01); G01N 30/70 (2006.01); G01N 30/72 (2006.01); G01N 30/88 (2006.01); G01N 33/00 (2006.01); G01N 33/18 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01); G01N 33/74 (2006.01); G01N 35/00 (2006.01); G01N 35/04 (2006.01); G01N 35/10 (2006.01); G06T 7/00 (2017.01); G06T 7/90 (2017.01); G16H 20/60 (2018.01); G16H 40/63 (2018.01); H10K 10/46 (2023.01); H10K 85/00 (2023.01); H10K 85/20 (2023.01);
U.S. Cl.
CPC ...
B01L 3/502761 (2013.01); B01L 3/502707 (2013.01); B01L 3/50273 (2013.01); B03C 1/01 (2013.01); B03C 1/0332 (2013.01); B03C 1/288 (2013.01); C12M 23/16 (2013.01); C12M 47/04 (2013.01); C12N 15/1058 (2013.01); G01N 33/54333 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/12 (2013.01); B01L 2400/043 (2013.01); B03C 2201/18 (2013.01); B03C 2201/26 (2013.01);
Abstract

Microfluidic devices, kits systems and methods are provided for high throughput phenotypic separation of magnetically labelled cell samples. The devices and methods can be used for example to sort cells based on level of target marker and to sort screen cells, such as CRISPR screen cells and other screens with a large number of target cells, to isolate target cells and putative genetic modifiers.

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