The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2025
Filed:
Sep. 10, 2024
Applicant:
Cytodigm, Inc., Natick, MA (US);
Inventors:
Assignee:
Cytodigm, Inc., Natick, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 9/51 (2006.01); A61K 38/46 (2006.01); C12N 15/113 (2010.01); C12N 15/88 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0033 (2013.01); A61K 9/5123 (2013.01); A61K 38/465 (2013.01); C12N 15/113 (2013.01); C12N 15/88 (2013.01); C12N 2310/14 (2013.01);
Abstract
The present invention provides a lipid nanoparticle (LNP) formulation comprising at least one sialic acid (SA)-containing lipid. The LNP formulation is capable of effectively binding cell surface Siglecs, transfecting certain cells in vitro and targeting certain cells in vivo. The present invention also provides methods of using the LNP compositions described herein for pharmaceutical applications. For example, the LNPs provided herein are useful for the intracellular delivery of a nucleic acid therapeutic to a subject.