The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 20, 2025

Filed:

Mar. 21, 2024
Applicant:

City of Hope, Duarte, CA (US);

Inventors:

Javier Gordon Ogembo, San Dimas, CA (US);

Lorraine Zvichapera Mutsvunguma, Duarte, CA (US);

Felix Wussow, Duarte, CA (US);

Assignee:

CITY OF HOPE, Duarte, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C07K 16/00 (2006.01); C07K 16/08 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); C07K 16/085 (2013.01); C12N 7/00 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55572 (2013.01); C07K 2317/76 (2013.01); C12N 2710/16222 (2013.01); C12N 2710/16223 (2013.01); C12N 2710/16234 (2013.01);
Abstract

Disclosed are vaccine compositions comprising a VLP comprising two or more EBV envelope glycoproteins and one or more T cell antigens and methods of preventing or treating EBV infections using the vaccine compositions. Also disclosed is an expression system or a single expression vector for co-expressing two or more EBV envelope glycoproteins simultaneously to generate a VLP vaccine. The expression system may include a single vector inserted with two or more nucleic acid sequences that encode two or more EBV envelope glycoproteins linked by one or more linking sequences such that the EBV envelope glycoproteins are co-expressed simultaneously.


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