The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2025
Filed:
Nov. 11, 2022
Flagship Pioneering Innovations Vii, Llc, Cambridge, MA (US);
Alexandra Rachael Sneider, Cambridge, MA (US);
Jacob Rosenblum Rubens, Cambridge, MA (US);
Narahari Subbanna Pujar, Berwyn, PA (US);
Molly Krisann Gibson, Medford, MA (US);
Benjamin Andrew Portney, Somerville, MA (US);
Geoffrey A. Von Maltzahn, Somerville, MA (US);
Camilo Ayala Breton, Andover, MA (US);
FLAGSHIP PIONEERING INNOVATIONS VII, LLC, Cambridge, MA (US);
Abstract
The disclosure provides, for example, single stranded, covalently closed DNA that does not form a double stranded structure longer than 100 base pairs. The ssDNA may encode an effector sequence, for instance a therapeutic protein. The ssDNA may comprise a nuclear targeting sequence (NTS). In some embodiments, the ssDNA shows decreased activation of the innate immune system compared to an otherwise similar dsDNA.