The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 20, 2025

Filed:

Jul. 19, 2022
Applicant:

Hoffman-la Roche Inc., Little Falls, NJ (US);

Inventors:

Susanne Kammler, Horsholm, DK;

Anais Lopez, Basel, CH;

Henrik Mueller, Basel, CH;

Soren Ottosen, Horsholm, DK;

Lykke Pedersen, Horsholm, DK;

Assignee:

HOFFMAN-LA ROCHE INC., Little Falls, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7105 (2006.01); A61K 31/712 (2006.01); A61P 31/20 (2006.01); C07H 21/02 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61K 31/712 (2013.01); A61P 31/20 (2018.01); C07H 21/02 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/341 (2013.01); C12N 2310/343 (2013.01); C12N 2310/346 (2013.01); C12N 2310/351 (2013.01); C12Y 207/07 (2013.01); C12Y 207/07007 (2013.01);
Abstract

The present invention relates to nucleic acid molecules that are complementary to both PAP associated domain containing 5 (PAPD5) and PAP associated domain containing 7 (PAPD7), leading to inhibition of the expression of both PAPD5 and PAPD7 when using a single nucleic acid molecule. The invention also provides for PAPD5 and PAPD7 specific nucleic acid molecules for use in treating and/or preventing a HBV infection, in particular a chronic HBV infection. Also comprised in the present invention is a pharmaceutical composition for use in the treatment and/or prevention of a HBV infection.


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