The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
Jan. 08, 2025
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Xiaoying Jin, Cambridge, MA (US);
Catherine O'Riordan, Cambridge, MA (US);
Lin Liu, Cambridge, MA (US);
Kate Zhang, Cambridge, MA (US);
Assignee:
Genzyme Corporation, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); C12N 15/86 (2006.01); G01N 30/72 (2006.01); G01N 30/02 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6848 (2013.01); C12N 15/86 (2013.01); G01N 30/72 (2013.01); C12N 2750/14123 (2013.01); C12N 2750/14143 (2013.01); G01N 2030/027 (2013.01);
Abstract
Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.