The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
Jun. 27, 2024
Guangzhou Reforgene Medicine Co., Ltd., Guangdong, CN;
Zhejiang Synsorbio Technology Co., Ltd, Zhejiang, CN;
Junbin Liang, Guangdong, CN;
Xingxiang Liang, Guangdong, CN;
Yang Sun, Zhejiang, CN;
Hui Xu, Guangdong, CN;
Kaiwei Si, Guangdong, CN;
Qiuting Li, Guangdong, CN;
Zhiqin Peng, Guangdong, CN;
Desheng Huangfu, Guangdong, CN;
GUANGZHOU REFORGENE MEDICINE CO., LTD., Guangzhou, CN;
ZHEJIANG SYNSORBIO TECHNOLOGY CO., LTD, Shaoxing, CN;
Abstract
The present invention relates to a CRISPR-Cas13 system and use thereof, and also relates to a Cas13 protein, a fusion protein, and a guide polynucleotide. The Cas13 protein has at least 90% sequence identity compared to SEQ ID NO: 1. The fusion protein comprises the Cas13 protein fused to a protein domain and/or a polypeptide tag. The guide polynucleotide comprises a same-direction repetition sequence and a guide sequence that has been engineered to hybridize with the target RNA. The same-direction repetition sequence has at least 70% sequence identity to any of SEQ ID NOs: 3 and 80-87. The CRISPR-Cas13 system comprises the Cas13 protein that has at least 90% sequence identity to SEQ ID NO: 1, or a coding nucleic acid therefor, and the guide polynucleotide or a coding nucleic acid therefor.