The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
Feb. 25, 2019
Applicant:
Beijing Meikang Geno-immune Biotechnology Co., Ltd., Beijing, CN;
Inventor:
Rui Zhang, Beijing, CN;
Assignee:
BEIJING MEIKANG GENO-IMMUNE BIOTECHNOLOGY CO., LTD., Beijing, CN;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/30 (2006.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); A61P 35/02 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/10 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 16/3061 (2013.01); A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464412 (2023.05); A61P 35/02 (2018.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 16/1045 (2013.01); C12N 5/0636 (2013.01); A61K 2039/804 (2018.08); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05);
Abstract
The present application provides a chimeric antigen receptor and application thereof. The chimeric antigen receptor comprises an antigen-binding domain, a transmembrane domain, a costimulatory signal transduction region, a CD3ζ signal transduction domain, and an inducible suicide fusion domain in tandem arrangement; wherein the antigen-binding domain binds to a tumor surface antigen and the tumor surface antigen is CD19.