The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
May. 29, 2020
Applicants:
Ludwig Institute for Cancer Research Ltd, Zurich, CH;
Centre Hospitalier Universitaire Vaudois, Lausanne, CH;
Université DE Lausanne, Lausanne, CH;
Inventors:
Assignees:
Ludwig Institute for Cancer Research Ltd, Zurich, CH;
Centre Hospitalier Universitaire Vaudois, Lausanne, CH;
Universite de Lausanne, Lausanne, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2851 (2013.01); A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/4633 (2023.05); A61K 39/464402 (2023.05); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); A61K 2039/505 (2013.01); A61K 2239/38 (2023.05); A61K 2239/46 (2023.05); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/41 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/75 (2013.01); C07K 2317/92 (2013.01); C07K 2319/03 (2013.01);
Abstract
Provided herein are antibodies and antigen-binding portions thereof that bind to tumor endothelial marker 1 (TEM1), as well as methods of using the disclosed antibodies and antigen-binding portions thereof, including methods of treating cancer, reducing tumor growth, reducing tumor metastasis, and/or reducing tumor-associated fibrosis in a subject in need thereof.