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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12297224 B1

PDFFull Text
Date of Patent:
May. 13, 2025

Filed:

Mar. 21, 2019

Crystal form, preparation method, and application of 4'-substituted nucleoside

Applicant:

Henan Genuine Biotech Co., Ltd., Pingdingshan, CN;

Inventors:

Junbiao Chang, Zhengzhou, CN;

Jinfa Du, Zhengzhou, CN;

Kaikai Zhu, Zhengzhou, CN;

Kai Wang, Zhengzhou, CN;

Jianyong Li, Zhengzhou, CN;

Chunxia Zhang, Zhengzhou, CN;

Assignee:

HENAN GENUINE BIOTECH CO., LTD., Pingdingshan, CN;

Attorneys:

MATTHIAS SCHOLL P.C.

Matthias Scholl

Primary Examiner:

Pancham Bakshi

Int. Cl.
CPC ...
C07H 19/16 (2006.01); A61K 31/505 (2006.01); A61K 31/5383 (2006.01); A61K 31/553 (2006.01); A61K 31/675 (2006.01); A61K 31/683 (2006.01); A61K 31/7068 (2006.01); A61K 31/7076 (2006.01); A61K 38/16 (2006.01); A61P 31/18 (2006.01); C07H 19/06 (2006.01);
U.S. Cl.
CPC ...
C07H 19/16 (2013.01); A61K 31/505 (2013.01); A61K 31/5383 (2013.01); A61K 31/553 (2013.01); A61K 31/675 (2013.01); A61K 31/683 (2013.01); A61K 31/7068 (2013.01); A61K 31/7076 (2013.01); A61K 38/162 (2013.01); A61P 31/18 (2018.01); C07H 19/06 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present invention discloses a crystal form, a preparation method and an application of a 4'-substituted nucleoside compound I having the following structure, including salts, prodrugs, and compositions thereof. Animal pharmacokinetic studies demonstrated that the effective drug concentrations of Compound Ia and Compound Ig in HIV target cells, peripheral blood mononuclear cells (PBMC), were effective in inhibiting HIV replication after 7 and 5 days, respectively. Therefore, Compound I can be used as a long-acting drug for preventing and treating AIDS. R is selected from ethynyl, azide, and cyano groups, X is selected from hydrogen and fluorine, and B is selected from B1 and B2.

Find Patent Forward Citations

Chang, Junbiao. (2025). Crystal form, preparation method, and application of 4'-substituted nucleoside (U.S. Patent No. 12297224). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12297224

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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