The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
Oct. 24, 2023
Applicant:
Aclaris Therapeutics, Inc., Wayne, PA (US);
Inventors:
Eric Jon Jacobsen, Chesterfield, MO (US);
David Randolph Anderson, Salem, CT (US);
James Robert Blinn, O'Fallon, MO (US);
Susan Landis Hockerman, Kirkwood, MO (US);
Richard Heier, Columbia, IL (US);
Paramita Mukherjee, Carbondale, IL (US);
Assignee:
Aclaris Therapeutics, Inc., Wayne, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 471/04 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 471/04 (2013.01); A61K 45/06 (2013.01);
Abstract
Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.