The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 13, 2025

Filed:

Apr. 26, 2023
Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Somasekhar Bhamidipati, Foster City, CA (US);

Simon Shaw, Oakland, CA (US);

Ihab Darwish, San Carlos, CA (US);

Jiaxin Yu, San Carlos, CA (US);

Rao Kolluri, Foster City, CA (US);

Vanessa Taylor, San Francisco, CA (US);

Esteban Masuda, Menlo Park, CA (US);

Mark Irving, San Francisco, CA (US);

Assignee:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/55 (2006.01); A61K 31/551 (2006.01); A61K 31/553 (2006.01); A61K 31/554 (2006.01); A61P 9/00 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 498/14 (2006.01); C07D 498/22 (2006.01); C07D 513/04 (2006.01); C07D 513/14 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01); C07D 498/22 (2013.01); C07D 513/14 (2013.01); C07D 519/00 (2013.01);
Abstract

Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.


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