The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 13, 2025

Filed:

Aug. 16, 2019
Applicant:

Htl Biotechnology Innovation Inc., Nutley, NJ (US);

Inventors:

Lixin Dai, Livingston, NJ (US);

Poonam Srivastava, Union City, NJ (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 8/66 (2006.01); A61K 8/65 (2006.01); A61K 8/9728 (2017.01); A61Q 19/00 (2006.01); C12N 1/16 (2006.01); C12N 9/02 (2006.01); C12R 1/84 (2006.01);
U.S. Cl.
CPC ...
A61K 8/66 (2013.01); A61K 8/65 (2013.01); A61K 8/9728 (2017.08); A61Q 19/00 (2013.01); C12N 1/165 (2021.05); C12N 9/0071 (2013.01); C07K 2319/00 (2013.01); C12R 2001/84 (2021.05); C12Y 114/11002 (2013.01);
Abstract

The disclosure herein provides a fusion protein comprising prolyl 4-hydroxylase alpha subunit (P4HA) and a soluble protein partner. A fusion protein comprising prolyl 4-hydroxylase alpha subunit (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB) is provided. A microorganism including a fusion protein comprising prolyl 4-hydroxylase alpha subunit-1 (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB) is provided. The disclosure provides a microorganism including a fusion protein comprising prolyl 4-hydroxylase alpha subunit-1 (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB); and another protein to be hydroxylated. A method for providing skincare benefits including applying the fusion protein of the present disclosure on skin is also taught.


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