The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 13, 2025

Filed:

Dec. 14, 2021
Applicants:

Tambo, Inc., San Francisco, CA (US);

The Research Foundation for the State University of New York, Albany, NY (US);

Inventors:

Jose Manuel Mejia Oneto, San Francisco, CA (US);

Nathan Yee, San Francisco, CA (US);

Maksim Royzen, San Francisco, CA (US);

Sangeetha Srinivasan, San Francisco, CA (US);

Ethan Miller, San Francisco, CA (US);

Assignee:

Tambo, Inc., San Francisco, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/61 (2017.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61K 49/00 (2006.01); A61P 31/04 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/545 (2017.08); A61K 45/06 (2013.01); A61K 47/542 (2017.08); A61K 47/61 (2017.08); A61K 49/0041 (2013.01); A61K 49/0043 (2013.01); A61K 49/0052 (2013.01); A61K 49/0054 (2013.01); A61P 31/04 (2018.01); A61P 35/00 (2018.01);
Abstract

Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.


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