The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
Dec. 02, 2021
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Chensu Wang, Allston, MA (US);
Karl Dane Wittrup, Boston, MA (US);
Darrell J. Irvine, Arlington, MA (US);
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/2013 (2013.01); A61K 39/0011 (2013.01); A61K 39/39 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61P 35/00 (2018.01); A61K 2039/507 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55561 (2013.01);
Abstract
The present disclosure provides a method of treating cancer with a priming dose of combination immunotherapy comprising IL-2 (e.g., extended-PK IL-2), an immune checkpoint inhibitor, a tumor targeting antibody or integrin-binding polypeptide, and optional cancer vaccine, administered prior to maintenance doses of immune checkpoint inhibitor therapy. The methods of the disclosure can be used to treat a broad range of cancer types.