The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
Oct. 04, 2023
Applicant:
City University of Hong Kong, Kowloon, HK;
Inventors:
Assignee:
CITY UNIVERSITY OF HONG KONG, Kowloon, HK;
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 5/055 (2006.01); A61B 6/00 (2006.01); A61K 9/1271 (2025.01); A61K 49/04 (2006.01); A61M 11/00 (2006.01);
U.S. Cl.
CPC ...
A61B 5/0042 (2013.01); A61B 5/055 (2013.01); A61B 6/481 (2013.01); A61K 9/1271 (2013.01); A61K 49/0438 (2013.01); A61M 11/00 (2013.01);
Abstract
Disclosed herein are methods for delivering a drug to the brain of a subject and monitoring the distribution of the drug therein. The method includes steps of: (a) intranasally administering of a first and second liposomes respectively loaded with the drug and a computed tomography (CT) contrast agent therein to the subject; (b) subjecting the brain of the subject of step (a) to a magnetic resonance imaging (MRI) scan; and (c) measuring chemical exchange saturation transfer (CEST) signals during the MRI scan in both olfactory bulb (OB) and frontal lobe (FL) regions at 1.2 ppm, 4.3 ppm, and −3.4 ppm, respectively.