The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 06, 2025

Filed:

Jun. 03, 2019
Applicant:

The Cleveland Clinic Foundation, Cleveland, OH (US);

Inventors:

Jonathan D. Smith, Shaker Heights, OH (US);

Stanley L. Hazen, Pepper Pike, OH (US);

Shuhui Wang Lorkowski, Shaker Heights, OH (US);

Assignee:

CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/92 (2005.12); G16H 15/00 (2017.12); G16H 50/30 (2017.12);
U.S. Cl.
CPC ...
G01N 33/92 (2012.12); G16H 15/00 (2017.12); G16H 50/30 (2017.12); G01N 2333/775 (2012.12);
Abstract

Provided herein are compositions, systems, kits, and methods for performing an apoA1 exchange assay to determine the risk of MACE and/or for conducting an action based on the assay results. In some embodiments, methods are provided for generating, or receiving, a report that graphically displays: i) the subjects ApoA1 exchange rate in a sample as lower than a control or threshold value, and ii) the subjects risk of a major adverse cardiac event (MACE) and/or cardiovascular disease as being higher than normal.


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