The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 06, 2025

Filed:

Jul. 25, 2019
Applicant:

Cornell University, Ithaca, NY (US);

Inventors:

Gennady Shvets, Ithaca, NY (US);

Glen Kelp, Ithaca, NY (US);

He Huang, Ithaca, NY (US);

Assignee:

Cornell University, Ithaca, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 21/552 (2013.12); B01L 3/00 (2005.12); G01N 21/35 (2013.12); G02B 5/00 (2005.12); G02B 21/06 (2005.12); G02B 21/36 (2005.12);
U.S. Cl.
CPC ...
G01N 21/554 (2012.12); B01L 3/502715 (2012.12); G01N 21/35 (2012.12); G02B 5/008 (2012.12); G02B 21/06 (2012.12); B01L 2300/0663 (2012.12); G02B 21/36 (2012.12);
Abstract

A detection unit, device, and system for cell capture, spectral analysis, and drug interaction monitoring. The detection unit includes an IR-transparent substrate connected to a plasmonic metasurface with an array of metallic antennas. In a detection device, the detection unit is connected to a microfluidic chamber with a channel such that the channel extends along the metasurface. For the detection system, the detection device is mounted on a microscope. The infrared spectra are collected in reflection, with infrared light impinging on the metasurface from the substrate side and returning back through the substrate in the form of reflected infrared light. The system includes a syringe pump for injecting live cells into the chamber. An AC source is connected to the metasurface for cell capture and its AC voltage creates a dielectrophoretic (DEP) force that causes the live cells to move from the chamber and onto the metasurface for spectral analysis.


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