The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 06, 2025

Filed:

Jul. 07, 2021
Applicants:

The University of Chicago, Chicago, IL (US);

Emd Millipore Corporation, Burlington, MA (US);

Inventors:

David A. Schwartz, Encinitas, CA (US);

Jimmy Williams, Santee, CA (US);

Xinfang Zhao, San Diego, CA (US);

Chunfang Zhao, San Diego, CA (US);

William B. Busa, Bahama, NC (US);

Stephen J. Kron, Oak Park, IL (US);

Amy Catherine Flor, Chicago, IL (US);

Assignees:

The University of Chicago, Chicago, IL (US);

EMD Millipore Corporation, Burlington, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6804 (2017.12); C07H 21/00 (2005.12); C12Q 1/6834 (2017.12);
U.S. Cl.
CPC ...
C12Q 1/6804 (2012.12); C07H 21/00 (2012.12); C12Q 1/6834 (2012.12);
Abstract

The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.


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