The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 06, 2025

Filed:

May. 24, 2022
Applicants:

H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);

University of South Florida, Tampa, FL (US);

Inventors:

Amod A. Sarnaik, Tampa, FL (US);

Shari Pilon-Thomas, Tampa, FL (US);

Mark McLaughlin, Tampa, FL (US);

Hao Liu, Tampa, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2009.12); A61K 35/12 (2014.12); A61K 39/00 (2005.12); G01N 33/50 (2005.12);
U.S. Cl.
CPC ...
C12N 5/0636 (2012.12); A61K 35/12 (2012.12); A61K 39/4611 (2023.04); A61K 39/46449 (2023.04); G01N 33/505 (2012.12); A61K 2239/57 (2023.04); C12N 2501/05 (2012.12); C12N 2501/056 (2012.12); C12N 2501/2302 (2012.12); C12N 2501/50 (2012.12); C12N 2501/998 (2012.12); C12N 2501/999 (2012.12);
Abstract

Disclosed are compositions and methods for ex vivo expansion of tumor infiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumor infiltrating lymphocytes for use in ACT. Also disclosed are methods for treating cancer using tumor-infiltrating lymphocytes expanded by the disclosed methods.


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