The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2025
Filed:
Sep. 11, 2018
Applicants:
Biontech Rna Pharmaceuticals Gmbh, Mainz, DE;
Tron-translationale Onkologie an Der Universitätsmedizin Der Johannes Gutenberg-universitat Mainz Gemein-nutzige Gmbh, Mainz, DE;
Inventors:
Marco Alexander Poleganov, Mainz, DE;
Mario Perkovic, Mainz, DE;
Ugur Sahin, Mainz, DE;
Tim Beissert, Mainz, DE;
Assignees:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2005.12); C12N 5/074 (2009.12);
U.S. Cl.
CPC ...
C12N 15/86 (2012.12); C12N 5/0696 (2012.12); C12N 2501/602 (2012.12); C12N 2501/603 (2012.12); C12N 2501/604 (2012.12); C12N 2501/605 (2012.12); C12N 2501/606 (2012.12); C12N 2501/608 (2012.12); C12N 2506/1307 (2012.12); C12N 2770/36143 (2012.12);
Abstract
The present invention embraces a RNA replicon that can be replicated by a replicase of alphavirus origin and comprises an open reading frame encoding a reprogramming factor. Such RNA replicons are useful for expressing a reprogramming factor in a cell, in particular a somatic cell. Cells engineered to express such reprogramming factors are useful in cell transplantation therapies.