The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2025
Filed:
Jun. 17, 2022
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Shawn Lawrence, Valley Cottage, NY (US);
Michelle Lafond, Pleasantville, NY (US);
Ann Kim, White Plains, NY (US);
Amy S. Johnson, Briarcliff Manor, NY (US);
Brandon Veres, White Plains, NY (US);
Mark Czeterko, Stamford, CT (US);
Kristen Whalen, Brookhaven, GA (US);
REGENERON PHARMACEUTICALS, INC., Tarrytown, NY (US);
Abstract
Improved methods for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, the method provides for culturing cells that have metabolically shifted. The use of such a method or system allows high levels of protein or polypeptide production and reduces accumulation of unwanted metabolic waste such as lactate. Proteins and polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical, immunogenic, or other commercial biologic compositions, such as antibodies.