The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2025
Filed:
Aug. 14, 2019
Applicant:
Shanghai Xingye Pharmaceutical Technology Co., Ltd, Shanghai, CN;
Inventors:
Weibin Song, Shanghai, CN;
Yanhui Liu, Shanghai, CN;
Assignee:
SHANGHAI XINGYE PHARMACEUTICAL TECHNOLOGY CO., LTD, Shanghai, CN;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/22 (2005.12); A61P 35/00 (2005.12);
U.S. Cl.
CPC ...
C07D 471/22 (2012.12); A61P 35/00 (2017.12);
Abstract
The present invention disclosed a series of novel matrine α-ketoamine derivatives as shown in formula I, which could inhibit the overexpression of TNF-α and/or activate the immune killing function of the NK cells, thus could be used to treat autoimmune diseases, inflammatory diseases, neurodegenerative diseases and tumors mediated by the abnormal levels of TNF-α and/or NK cell dysfunction.