The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 06, 2025

Filed:

Jul. 20, 2018
Applicants:

Universidade Federal DE Minas Gerais, Belo Horizonte, BR;

Fundacao DE Amparo a Pesquisa DO Estado DE Minas Gerais—fapemig, Belo Horizonte, BR;

Inventors:

Angelo De Fatima, Belo Horizonte, BR;

Frederico Duarte Garcia, Belo Horizonte, BR;

Simone Odilia Antunes Fernandes, Belo Horizonte, BR;

Valbert Nascimento Cardoso, Belo Horizonte, BR;

Adriana Martins Godin, Belo Horizonte, BR;

Angelica Faleiros Da Silva Maia, Belo Horizonte, BR;

Leonardo Da Silva Neto, Belo Horizonte, BR;

Maila De Castro Lourenco Das Neve, Belo Horizonte, BR;

Paulo Sergio De Almeida Augusto, Betim, BR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 451/12 (2005.12); A61K 39/385 (2005.12); A61P 25/36 (2005.12); A61K 39/00 (2005.12); C07C 69/732 (2005.12);
U.S. Cl.
CPC ...
C07D 451/12 (2012.12); A61K 39/385 (2012.12); A61P 25/36 (2017.12); A61K 2039/60 (2012.12); C07C 69/732 (2012.12);
Abstract

This technology relates to immune system stimulating molecules to be used in the treatment of drug addiction and abuse and their synthesis processes. These molecules have a calixarene chemical structure, preferably calix[4]arene and/or calix[8]arene, coupled to an hapten analogous to cocaine, preferably GNE and/or GNC. An anti-drug vaccine, specifically anti-cocaine, is also described using such molecules. The anti-drug vaccine can be also used to prevent fetal exposure to drugs in pregnant women who use drugs and do not wish or cannot stop their use during pregnancy.


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