The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2025
Filed:
Dec. 13, 2022
Zheming Wang, Hangzhou, CN;
Rushi Biotech (Hangzhou) Co., Ltd, Hangzhou, CN;
Zheming Wang, Hangzhou, CN;
Hao Tan, Hangzhou, CN;
[object Object];
Rushi Biotech (Hangzhou) Co., Ltd, Hangzhou, CN;
Abstract
The present invention discloses a pyrrolidine derivative or its optically active isomer, or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NADexpression. The pyrrolidine derivative has pyrrolidine as a parent structure, to which pyridinylurea (or substituted pyridinylurea) is attached by an intermediate aliphatic chain, and a side arylformyl (or heterocyclylformyl) group is attached. This structure is an optimized structure of the NAMPT inhibitor FK866, in which the acrylamido group is replaced by a urea structure, to increases the water solubility of the compound. Moreover, the difficulty in synthesis is reduced accordingly, which is conducive to the subsequent industrial production.