The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2025
Filed:
Apr. 14, 2020
Newron Pharmaceuticals S.p.a., Bresso, IT;
William Leong, Westfield, NJ (US);
Dongxiao Lan, Shanghai, CN;
Weifang Zhang, Shanghai, CN;
Xiang Fang, Shanghai, CN;
Sizhong Wu, Shanghai, CN;
Newron Pharmaceuticals S.p.A., Bresso, IT;
Abstract
The present invention refers to a process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R is (C-C)alkyl, or ω-trifluoro(C-C)alkyl; Rand Rare, independently, hydrogen, hydroxy, (C-C) alkoxy, (C-C) alkylthio, halo, trifluoromethyl or 2,2,2-trifluoroethyl; or one of Rand Ris in ortho position to the R—O— group and, taken together with the same R—O—, represents a Formula (A) group where Ris (C-C)alkyl; Rand Rare, independently, hydrogen, (C-C)alkyl; or Ris hydrogen and Ris a group selected from —CH—OH, —CH—O—(C-C)alkyl, —CH(CH)—OH, —(CH)—S—CH, benzyl and 4-hydroxybenzyl; or Rand R, taken together with the adjacent carbon atom, form a (C-C)cycloalkyl residue; Rand Rare independently hydrogen or (C-C)alkyl; or taken together with the adjacent nitrogen atom form a 5-6 membered monocyclic saturated heterocycle, optionally containing one additional heteroatom chosen among —O—, —S— and —NR— where Ris hydrogen or (C-C) alkyl; and wherein optionally one or more hydrogen atom in the groups R, R, R, R, R, Rand R, preferably in the R group, can be substituted by a deuterium atom.