The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2025
Filed:
Oct. 24, 2023
Applicants:
Virion Therapeutics, Llc, Newark, DE (US);
The Wistar Institute, Philadelphia, PA (US);
Inventors:
Hildegund C J Ertl, Villanova, PA (US);
Colin Stephen Magowan, Bishop, CA (US);
Assignees:
Virion Therapeutics, LLC, Newark, DE (US);
The Wistar Institute, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/29 (2005.12); A61K 35/761 (2014.12); A61K 38/00 (2005.12); A61K 39/00 (2005.12); A61K 39/12 (2005.12); A61P 31/12 (2005.12); C12N 7/00 (2005.12); C12N 15/86 (2005.12);
U.S. Cl.
CPC ...
A61K 39/292 (2012.12); A61P 31/12 (2017.12); C12N 7/00 (2012.12); C12N 15/86 (2012.12); A61K 2039/53 (2012.12); C12N 2710/10343 (2012.12); C12N 2730/10122 (2012.12); C12N 2730/10134 (2012.12);
Abstract
Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.