The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2025
Filed:
Jun. 20, 2019
Applicant:
Imagine Pharma Llc, Devon, PA (US);
Inventors:
Ngoc Thai, Pittsburgh, PA (US);
Jonathan Pollett, Pittsburgh, PA (US);
Assignee:
Imagine Pharma LLC, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/39 (2014.12); C12N 5/00 (2005.12); C12N 5/071 (2009.12);
U.S. Cl.
CPC ...
A61K 35/39 (2012.12); C12N 5/0678 (2012.12); C12N 2501/998 (2012.12);
Abstract
Disclosed herein are compositions and methods to differentiate pancreatic cells into functional insulin-producing CD133/Ki-67-positive activated islet proliferating cells (AIPCs) derived from isolated pancreatic islets and expand derived-AIPCs in in vitro cultures using a culture medium comprising an active agent. Also disclosed herein is the use of the AIPCs for implantation into a mammal for in vivo therapy, specifically for pancreatic disorders, including diabetes type I.