The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
Nov. 27, 2020
Method and compositions for predicting anti-cancer efficacy of compounds targeting apoptosis pathway
Ascentage Pharma (Suzhou) Co., Ltd., Jiangsu, CN;
Ascentage Pharma Group Corp Limited, Hong Kong, CN;
Yifan Zhai, Jiangsu, CN;
Dajun Yang, Jiangsu, CN;
Douglas Dong Fang, Jiangsu, CN;
Ran Tao, Jiangsu, CN;
Ascentage Pharma (Suzhou) Co., Ltd., Jiangsu, CN;
Ascentage Pharma Group Corp Limited, Hong Kong, CN;
Abstract
Provided are biomarkers for predicting the efficacy of MDM2 inhibitor or Bcl-2/Bcl-xL dual inhibitors or Bcl-2 inhibitor or Bcl-xL inhibitor in treating cancer patients. Also provided are compositions, e.g., kits, for evaluating gene levels of the biomarkers and methods of using such gene levels to predict a cancer patient's response to the MDM2 inhibitors or Bcl-2/Bcl-xL dual inhibitors or Bcl-2 inhibitor or Bcl-xL inhibitor. Such information can be used in determining prognosis and treatment options for cancer patients.