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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12286487 B1

PDFFull Text
Date of Patent:
Apr. 29, 2025

Filed:

Oct. 08, 2019

Antibody compounds with reactive arginine and related antibody drug conjugates

Applicant:

University of Florida Research Foundation, Incorporated, Gainesville, FL (US);

Inventors:

Christoph Rader, Jupiter, FL (US);

Dobeen Hwang, Palm Beach Gardens, FL (US);

Napon Nilchan, Jupiter, FL (US);

Assignee:

University Of Florida Research Foundation, Incorporated, Gainesville, FL (US);

Attorney:

Alston & Bird LLP

Primary Examiner:

Daniel E Kolker

Assistant Examiner:

Maureen Varina Driscoll

Int. Cl.
CPC ...
C07K 16/44 (2005.12); A61K 47/54 (2016.12); A61K 47/68 (2016.12); C07K 16/32 (2005.12);
U.S. Cl.
CPC ...
C07K 16/44 (2012.12); A61K 47/542 (2017.07); A61K 47/68031 (2023.07); A61K 47/6851 (2017.07); C07K 16/32 (2012.12); C07K 2317/24 (2012.12); C07K 2317/31 (2012.12); C07K 2317/55 (2012.12);
Abstract

The present invention provides antibody compounds that contain a substitution of arginine for the reactive lysine residue (Lys99) in the hydrophobic cleft (38C2_Arg). The invention also provides antibody drug conjugate compounds (ADCs) that contain cargo moieties that are site-specifically conjugated to the engineered arginine residue in the 38C2_Arg variant antibody. Further provided in the invention are therapeutic applications of the compounds.

Find Patent Forward Citations

Rader, Christoph. (2025). Antibody compounds with reactive arginine and related antibody drug conjugates (U.S. Patent No. 12286487). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12286487

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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