The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
Jan. 23, 2019
Applicant:
Nextcure, Inc., Beltsville, MD (US);
Inventors:
Solomon Langermann, Baltimore, MD (US);
Dallas Benjamin Flies, Rockville, MD (US);
Linda Liu, Clarksville, MD (US);
Assignee:
NextCure, Inc., Beltsville, MD (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2005.12); C07K 14/705 (2005.12);
U.S. Cl.
CPC ...
C07K 16/2827 (2012.12); C07K 14/70532 (2012.12); C07K 2317/31 (2012.12); C07K 2317/51 (2012.12); C07K 2317/515 (2012.12); C07K 2317/565 (2012.12); C07K 2317/732 (2012.12);
Abstract
Compositions and methods of use thereof for modulating B7-H4 are provided. For example, immunomodulatory agents are provided that reduce B7-H4 expression, ligand binding, crosslinking, negative signaling, or a combination thereof. Such agents can be used to increase an immune response in a subject in need thereof. Immunomodulatory agents are also provided that increase B7-H4 expression, ligand binding, crosslinking, negative signaling, or a combination thereof. Such agents can be used to reduce an immune response in a subject in need thereof.