The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 29, 2025

Filed:

Jul. 18, 2018
Applicants:

The University of British Columbia, Vancouver, CA;

Promis Neurosciences Inc., Toronto, CA;

Inventors:

Neil R. Cashman, Vancouver, CA;

Steven S. Plotkin, Vancouver, CA;

Johanne Kaplan, Sherborn, MA (US);

Judith Maxwell Silverman, Whistler, CA;

Ebrima Gibbs, Port Moody, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2005.12); A61K 39/00 (2005.12); A61K 51/10 (2005.12); A61P 25/28 (2005.12); C07K 16/00 (2005.12); C07K 16/18 (2005.12); G01N 33/68 (2005.12);
U.S. Cl.
CPC ...
C07K 16/18 (2012.12); A61K 51/1018 (2012.12); A61P 25/28 (2017.12); G01N 33/6896 (2012.12); A61K 2039/505 (2012.12); C07K 2317/00 (2012.12); C07K 2317/24 (2012.12); C07K 2317/30 (2012.12); C07K 2317/31 (2012.12); C07K 2317/50 (2012.12); C07K 2317/51 (2012.12); C07K 2317/515 (2012.12); C07K 2317/54 (2012.12); C07K 2317/55 (2012.12); C07K 2317/56 (2012.12); C07K 2317/565 (2012.12); C07K 2317/569 (2012.12); C07K 2317/60 (2012.12); C07K 2317/62 (2012.12); C07K 2317/622 (2012.12); C07K 2317/624 (2012.12); C07K 2317/626 (2012.12); C07K 2317/64 (2012.12); C07K 2317/66 (2012.12); C07K 2317/76 (2012.12); C07K 2317/92 (2012.12); G01N 2333/4709 (2012.12);
Abstract

The disclosure pertains to antibodies that bind A-beta oligomers and methods of making and using said antibodies. Also provided are chimeric or humanized antibodies, including antibodies having CDRs in Table 2 and/or having a sequence as set forth in Table 4B or a sequence with at least 50% sequence identity thereto optionally wherein the CDR amino acid sequences are as set for forth in SEQ ID Nos: 74-79. Also provided are methods and uses thereof as well as kits comprising said antibodies.


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