The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 29, 2025

Filed:

Apr. 05, 2022
Applicant:

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

Inventors:

John A. Copland, Iii, Ponte Vedra Beach, FL (US);

Han W. Tun, Jacksonville, FL (US);

Thomas R. Caulfield, Jacksonville, FL (US);

Christina Von Roemeling, Jacksonville, FL (US);

Laura Ann Marlow, Jacksonville, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 295/192 (2005.12); A61K 31/44 (2005.12); A61K 31/495 (2005.12); A61K 31/496 (2005.12); A61K 45/06 (2005.12); C07D 211/64 (2005.12); C07D 211/66 (2005.12); C07D 213/64 (2005.12); C07D 213/75 (2005.12);
U.S. Cl.
CPC ...
C07D 295/192 (2012.12); A61K 31/44 (2012.12); A61K 31/495 (2012.12); A61K 31/496 (2012.12); A61K 45/06 (2012.12); C07D 211/64 (2012.12); C07D 211/66 (2012.12); C07D 213/64 (2012.12); C07D 213/75 (2012.12);
Abstract

This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.


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