The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 29, 2025

Filed:

Mar. 20, 2019
Applicant:

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Inventors:

Juan M. Taboas, Pittsburgh, PA (US);

Herbert L. Ray, Leechburg, PA (US);

Jingming Chen, Pittsburgh, PA (US);

Patrick Eugene Donnelly, Pittsburgh, PA (US);

Tyler Swenson, Pittsburgh, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/52 (2005.12); A61L 27/48 (2005.12); A61L 27/54 (2005.12); A61L 27/56 (2005.12);
U.S. Cl.
CPC ...
A61L 27/52 (2012.12); A61L 27/48 (2012.12); A61L 27/54 (2012.12); A61L 27/56 (2012.12); A61L 2300/222 (2012.12); A61L 2300/41 (2012.12); A61L 2300/414 (2012.12); A61L 2300/426 (2012.12); A61L 2400/06 (2012.12); A61L 2430/12 (2012.12);
Abstract

Methods of regenerating vital tooth tissue in situ after endodontic therapy include introducing a hydrogel scaffold into a root canal of a tooth in a patient after native pulp has been removed from the root canal. The hydrogel scaffold may comprise a sponge scaffold, and can be acellular. The hydrogel scaffold can contain chemotactic, angiogenic, neurogenic, and/or immunomodulatory biofactors that cause infiltration of endogenous cells from the patient into the root canal. Alternatively, such biofactors/drugs can be administered to the patient separately from the hydrogel scaffold. The hydrogel scaffold can fill the periapical space of an abscessed root.


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