The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
Dec. 27, 2021
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Umar Mahmood, Winchester, MA (US);
Benjamin Larimer, Woburn, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2005.12); A61K 51/08 (2005.12); A61P 31/00 (2005.12); C07K 7/08 (2005.12);
U.S. Cl.
CPC ...
A61K 51/088 (2012.12); A61K 38/10 (2012.12); A61P 31/00 (2017.12); C07K 7/08 (2012.12);
Abstract
Provided herein are compositions of Formula I useful for imaging HER3. The structure of Formula I is A-B-C, where A is an imaging agent, B is a linking group or a covalent bond, and C is a polypeptide comprising from about 9 to about 75 amino acids and contains a disulfide bond between two cysteine groups. An exemplary composition provided herein is useful as a radiotracer for position emission tomography (PET) imaging. Methods of imaging HER3 and combination therapies comprising the HER3 imaging agents are also provided.