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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12285495 B1

PDFFull Text
Date of Patent:
Apr. 29, 2025

Filed:

Oct. 15, 2019

Genome editing methods and constructs

Applicant:

Fondazione Telethon, Rome, IT;

Inventors:

Alberto Auricchio, Pozzuoli, IT;

Manel Llado Santaeularia, Pozzuoli, IT;

Assignee:

FONDAZIONE TELETHON ETS, Rome, IT;

Attorneys:

Silvia Salvadori, P.C.

Silvia Salvadori

Primary Examiner:

Robert B Mondesi

Assistant Examiner:

Mohammad Y Meah

Int. Cl.
CPC ...
C12N 9/00 (2005.12); A61K 48/00 (2005.12); A61P 27/02 (2005.12); C12N 9/22 (2005.12); C12N 15/11 (2005.12); C12N 15/90 (2005.12);
U.S. Cl.
CPC ...
A61K 48/0058 (2012.12); A61P 27/02 (2017.12); C12N 9/22 (2012.12); C12N 15/11 (2012.12); C12N 15/907 (2012.12); C12N 2310/20 (2017.04); C12N 2750/14143 (2012.12);
Abstract

The present invention relates to a method of integrating an exogenous DNA sequence into a genome of a cell comprising contacting the cell with: a) a donor nucleic acid comprising: —at least one STOP codon and a translation initiation sequence (TIS) or—a ribosomal skipping sequence, and—said exogenous DNA sequence wherein said donor nucleic acid is flanked at 5' and 3′ by inverted targeting sequences; b) a complementary strand oligonucleotide homologous to the targeting sequence and c) a nuclease that recognizes the targeting sequence.

Find Patent Forward Citations

Auricchio, Alberto. (2025). Genome editing methods and constructs (U.S. Patent No. 12285495). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12285495

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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