The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
May. 10, 2021
Applicant:
Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;
Inventors:
Vittoria Zinzalla, Vienna, AT;
Klaus-Peter Kuenkele, Perchtoldsdorf, AT;
Marie-Ange Buyse, Merelbeke, BE;
Karen Cromie, Merelbeke, BE;
Stephanie Staelens, Wevelgem, BE;
Beatrijs Strubbe, Oostakker, BE;
Assignee:
Ablynx N.V., Zwijnaarde, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2005.12); A61K 47/68 (2016.12); A61P 35/00 (2005.12); C07D 519/04 (2005.12); C07K 16/18 (2005.12); C07K 16/28 (2005.12); C07K 16/46 (2005.12);
U.S. Cl.
CPC ...
A61K 47/6849 (2017.07); A61K 39/00 (2012.12); A61P 35/00 (2017.12); C07D 519/04 (2012.12); C07K 16/18 (2012.12); C07K 16/28 (2012.12); C07K 16/46 (2012.12); A61K 2039/505 (2012.12); C07K 2317/22 (2012.12); C07K 2317/31 (2012.12); C07K 2317/569 (2012.12); C07K 2317/76 (2012.12);
Abstract
The invention provides LRP5-binding polypeptides, and more specifically LRP5-binding immunoglobulin single variable domain constructs which can inhibit Wnt signaling pathways. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as cancer.