The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
Apr. 18, 2017
Applicants:
The Trustees of Columbia University IN the City of New York, New York, NY (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Inventors:
Ira Tabas, New City, NY (US);
Xiaobo Wang, Fort Lee, NJ (US);
Omid Farokhzad, Waban, MA (US);
Xiaoding Xu, Malden, MA (US);
Assignees:
The Trustees of Columbia University in the City of New York, New York, NY (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2009.12); A61K 9/1271 (2024.12); A61K 9/50 (2005.12); A61K 31/4178 (2005.12); A61K 31/4439 (2005.12); A61K 31/7105 (2005.12); A61K 31/713 (2005.12); A61K 38/17 (2005.12); A61K 47/69 (2016.12); A61K 48/00 (2005.12); A61P 1/16 (2005.12); G01N 33/50 (2005.12); G01N 33/68 (2005.12); A61K 45/06 (2005.12);
U.S. Cl.
CPC ...
A61K 38/17 (2012.12); A61K 9/1271 (2012.12); A61K 9/5073 (2012.12); A61K 31/4178 (2012.12); A61K 31/4439 (2012.12); A61K 31/7105 (2012.12); A61K 31/713 (2012.12); A61K 47/6929 (2017.07); A61P 1/16 (2017.12); C12N 15/113 (2012.12); G01N 33/50 (2012.12); G01N 33/6893 (2012.12); A61K 45/06 (2012.12); C12N 2310/14 (2012.12); C12N 2320/32 (2012.12);
Abstract
The present invention relates to methods and compositions for specifically modulating the Hippo pathway transcription factor TAZ (WWTR1), as a therapeutic target for inhibiting or preventing liver conditions including the progression of steatosis-to-NASH in a patient.