The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
Dec. 10, 2021
Applicant:
Omniox, Inc., San Carlos, CA (US);
Inventors:
Stephen P. L. Cary, San Mateo, CA (US);
Ana Krtolica, San Francisco, CA (US);
Natacha Le Moan, San Francisco, CA (US);
Jonathan A Winger, Oakland, CA (US);
Kevin G. Leong, Millbrae, CA (US);
Assignee:
Omniox, Inc., San Francisco, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2005.12); A61K 39/39 (2005.12); A61K 39/395 (2005.12); A61K 45/06 (2005.12); A61K 47/60 (2016.12); A61P 35/00 (2005.12); C07K 16/28 (2005.12); A61N 5/10 (2005.12);
U.S. Cl.
CPC ...
A61K 38/164 (2012.12); A61K 39/39 (2012.12); A61K 45/06 (2012.12); A61K 47/60 (2017.07); A61P 35/00 (2017.12); A61N 5/10 (2012.12); A61N 2005/1098 (2012.12);
Abstract
The invention provides methods to modulate hypoxia-mediated tumor immunity by administration of an Ocarrier polypeptide (e.g., an H-NOX protein). The methods of the invention target both hypoxia inducible factor 1 alpha (HIF-1α) pathways and non-HIF-1α pathways of tumor immunity. Such methods are useful in the treatment of a wide variety of cancers and may be used alone or in combination with other anti-cancer therapies.