The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
May. 30, 2023
Applicants:
University of Rhode Island Board of Trustees, Kingston, RI (US);
Yale University, New Haven, CT (US);
Inventors:
Yana K. Reshetnyak, Saunderstown, RI (US);
Oleg A. Andreev, Saunderstown, RI (US);
Anna Moshnikova, Warwick, RI (US);
Donald M. Engelman, New Haven, CT (US);
Assignees:
University of Rhode Island Board of Trustees, Kingston, RI (US);
Yale University, New Haven, CT (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2005.12); A61K 38/16 (2005.12); A61K 38/19 (2005.12); A61K 38/20 (2005.12); A61K 45/00 (2005.12); A61K 47/00 (2005.12); A61K 47/10 (2016.12);
U.S. Cl.
CPC ...
A61K 38/16 (2012.12); A61K 38/195 (2012.12); A61K 38/20 (2012.12); A61K 45/05 (2012.12); A61K 47/00 (2012.12); A61K 47/10 (2012.12); A61K 2121/00 (2012.12); C07K 2319/33 (2012.12);
Abstract
The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIPconstruct comprising an antibody recruiting molecule linked to one or more pHLIPpeptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.