The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
Dec. 03, 2021
Applicant:
Duke University, Durham, NC (US);
Inventors:
Conrad P. Hodgkinson, Durham, NC (US);
Victor J. Dzau, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/33 (2014.12); C12N 5/077 (2009.12); C12N 15/113 (2009.12);
U.S. Cl.
CPC ...
A61K 35/33 (2012.12); C12N 5/0657 (2012.12); C12N 15/113 (2012.12); C12N 2310/141 (2012.12); C12N 2320/31 (2012.12); C12N 2501/65 (2012.12); C12N 2501/999 (2012.12); C12N 2506/1307 (2012.12);
Abstract
The invention provides a method of promoting reprogramming of a cardiac fibroblast into a cardiomyocyte by contacting the cardiac fibroblast with an isolated polynucleotide molecule comprising at least two functional miRNA sequences using a multicistronic expression system for reprogramming of fibroblasts into functional mature cardiomyocytes.