The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
Aug. 07, 2023
Buck Institute for Research on Aging, Novato, CA (US);
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Unity Biotechnology, Inc., South San Francisco, CA (US);
Remi-Martin Laberge, South San Francisco, CA (US);
Judith Campisi, Berkeley, CA (US);
Marco Demaria, San Francisco, CA (US);
Bennett G. Childs, Rochester, MN (US);
Jan M. A. Van Deursen, Rochester, MN (US);
Nathaniel David, South San Francisco, CA (US);
Alain Philippe Vasserot, South San Francisco, CA (US);
Unity Biotechnology, Inc., South San Francisco, CA (US);
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Buck Institute for Research on Aging, Novato, CA (US);
Abstract
This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.