The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2025

Filed:

Nov. 11, 2020
Applicant:

Quest Diagnostics Investments Incorporated, Wilmington, DE (US);

Inventors:

Mildred Goldman, Laguna Niguel, CA (US);

Nigel J. Clarke, Vista, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2005.12); G01N 30/72 (2005.12); G01N 33/74 (2005.12); H01J 49/00 (2005.12); H01J 49/26 (2005.12);
U.S. Cl.
CPC ...
G01N 33/743 (2012.12); G01N 30/724 (2012.12); G01N 33/6848 (2012.12); G01N 33/6851 (2012.12); H01J 49/0027 (2012.12); G01N 2458/15 (2012.12); H01J 49/00 (2012.12);
Abstract

Methods are provided for detecting the amount of one or more HRT panel analytes (i.e., estrone (E1), estrone sulfate (E1s), 17α-estradiol (E2a), 17β-estradiol (E2b), estradiol sulfate (E2s), estriol (E3), equilin (EQ), 17α-dihydroequilin (EQa), 17β-dihydroequilin (EQb), Equilenin (EN), 17α-dihydroequilenin (ENa), 17β-dihydroequilenin (ENb), and Δ8,9-dehydroestrone (dE1)) in a sample by mass spectrometry. The methods generally involve ionizing one or more HRT panel analytes in a sample and quantifying the generated ions to determine the amount of one or more HRT panel analytes in the sample. In methods where amounts of multiple HRT panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.


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