The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Apr. 14, 2024
Applicants:
California Institute of Technology, Pasadena, CA (US);
Molecular Instruments, Inc., Los Angeles, CA (US);
Inventors:
Harry M T Choi, South Pasadena, CA (US);
Chun Hao R. Chen, Los Angeles, CA (US);
Mike C. Liu, Los Angeles, CA (US);
Aneesh Acharya, Altadena, CA (US);
Niles A. Pierce, Pasadena, CA (US);
Assignees:
California Institute of Technology, Pasadena, CA (US);
Molecular Instruments, Inc., Los Angeles, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/682 (2017.12); C12Q 1/6818 (2017.12); C12Q 1/6841 (2017.12);
U.S. Cl.
CPC ...
C12Q 1/682 (2012.12); C12Q 1/6818 (2012.12); C12Q 1/6841 (2012.12);
Abstract
The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.