The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Sep. 25, 2019
Applicants:
Case Western Reserve University, Cleveland, OH (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Inventors:
Jeffery M. Coller, Novelty, OH (US);
Thomas Sweet, Cleveland, OH (US);
Harvey Lodish, Cambridge, MA (US);
Assignees:
CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US);
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/67 (2005.12); A61K 31/7088 (2005.12); A61K 45/06 (2005.12); A61K 48/00 (2005.12); A61P 43/00 (2005.12); C12N 15/11 (2005.12); C12N 15/86 (2005.12);
U.S. Cl.
CPC ...
C12N 15/67 (2012.12); A61K 31/7088 (2012.12); A61K 45/06 (2012.12); A61K 48/0066 (2012.12); A61P 43/00 (2017.12); C12N 15/11 (2012.12); C12N 15/86 (2012.12); C12N 2750/14143 (2012.12);
Abstract
A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.