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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12281314 B1

PDFFull Text
Date of Patent:
Apr. 21, 2025

Filed:

Sep. 25, 2019

Methods and compositions for increasing protein expression and/or treating a haploinsufficiency disorder

Applicants:

Case Western Reserve University, Cleveland, OH (US);

Whitehead Institute for Biomedical Research, Cambridge, MA (US);

Inventors:

Jeffery M. Coller, Novelty, OH (US);

Thomas Sweet, Cleveland, OH (US);

Harvey Lodish, Cambridge, MA (US);

Assignees:

CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US);

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, Cambridge, MA (US);

Attorney:

Tarolli, Sundheim, Covell & Tummino LLP

Primary Examiner:

Fereydoun G Sajjadi

Assistant Examiner:

Qinhua Gu

Int. Cl.
CPC ...
C12N 15/67 (2005.12); A61K 31/7088 (2005.12); A61K 45/06 (2005.12); A61K 48/00 (2005.12); A61P 43/00 (2005.12); C12N 15/11 (2005.12); C12N 15/86 (2005.12);
U.S. Cl.
CPC ...
C12N 15/67 (2012.12); A61K 31/7088 (2012.12); A61K 45/06 (2012.12); A61K 48/0066 (2012.12); A61P 43/00 (2017.12); C12N 15/11 (2012.12); C12N 15/86 (2012.12); C12N 2750/14143 (2012.12);
Abstract

A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.

Find Patent Forward Citations

Coller, Jeffery. (2025). Methods and compositions for increasing protein expression and/or treating a haploinsufficiency disorder (U.S. Patent No. 12281314). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12281314

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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