The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Apr. 01, 2019
Applicant:
Shenzhen University, Guangdong, CN;
Inventors:
Assignee:
SHENZHEN UNIVERSITY, Shenzhen, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/52 (2005.12); A61K 47/54 (2016.12); A61K 47/64 (2016.12); A61K 47/68 (2016.12); A61P 35/00 (2005.12); C07D 473/18 (2005.12);
U.S. Cl.
CPC ...
C07D 473/18 (2012.12); A61K 31/52 (2012.12); A61K 47/54 (2017.07); A61K 47/545 (2017.07); A61K 47/64 (2017.07); A61K 47/6803 (2017.07); A61P 35/00 (2017.12);
Abstract
Provided is a series of homologous small molecule immune agonists and novel bifunctional immune targeting compounds having targeting and immune activation functions, which are obtained by coupling the small molecule immune agonists to targeting drugs. The resulting immune targeting compounds are beneficial for enhancing immune activation effects, and anti-tumor and other disease fighting effects of the targeting drug. The enhanced effect is produced from a synergy of immunological anti-tumor factors (such as IFN-γ) and inhibition at pathogenic targeting sites.