The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2025

Filed:

Jun. 10, 2021
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Leslie A. Dakin, Framingham, MA (US);

Timothy J. Senter, Arlington, MA (US);

Jingrong Cao, Newton, MA (US);

Jon H. Come, Cambridge, MA (US);

Francois Denis, St-Lazare, CA;

Warren A. Dorsch, Waltham, MA (US);

Anne Fortier, Jamaica Plain, MA (US);

Martine Hamel, Laval, CA;

Elaine B. Krueger, Milton, MA (US);

Brian Ledford, Norton, MA (US);

Francois Maltais, Stoneham, MA (US);

Suganthini S. Nanthakumar, Newton, MA (US);

Olivier Nicolas, Montreal, CA;

Camil E. Sayegh, Belmont, MA (US);

Tiansheng Wang, Concord, MA (US);

Stephanie Dorich, Pointe-Claire, CA;

Lee Fader, Hawkesbury, CA;

Claudio Sturino, Ile Bizard, CA;

Janek Szychowski, Montreal, CA;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/14 (2005.12); C07D 401/12 (2005.12); C07D 403/08 (2005.12); C07D 403/12 (2005.12); C07D 405/12 (2005.12); C07D 409/12 (2005.12); C07D 413/12 (2005.12); C07D 417/12 (2005.12); C07D 471/04 (2005.12);
U.S. Cl.
CPC ...
C07D 403/12 (2012.12); C07D 209/14 (2012.12); C07D 401/12 (2012.12); C07D 403/08 (2012.12); C07D 405/12 (2012.12); C07D 409/12 (2012.12); C07D 413/12 (2012.12); C07D 417/12 (2012.12); C07D 471/04 (2012.12); C07B 2200/05 (2012.12);
Abstract

The disclosure provides at least one compound, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of formula (I), deuterated derivatives thereof, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease.


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