The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Jul. 14, 2019
University of Kansas, Lawrence, KS (US);
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA (US);
Northeastern University, Boston, MA (US);
Clarkson University, Potsdam, NY (US);
Steven A. Soper, Baton Rouge, LA (US);
Collin J. McKinney, Durham, NC (US);
Elizabeth Podlaha-Murphy, Potsdam, NY (US);
Sunggook Park, Baton Rouge, LA (US);
University of Kansas, Lawrence, KS (US);
Univ. of N Carolina at Chapel Hill, Chapel Hill, NC (US);
Board of Supervisors of LSU and A&M College, Baton Rouge, LA (US);
Northeastern University, Boston, MA (US);
Clarkson University, Potsdam, NY (US);
Abstract
Disclosed are nanofluidic analytical devices. The devices employ a sample processing region that includes a plurality of fluidically connected sample handling elements that, in combination, affect a physical change on a sample introduced into the sample processing region. This physical change can include, for example, purification of an analyte of interest present in the sample, concentration of an analyte of interest present in the sample, chemical modification (e.g., cleavage and/or chemical derivatization) of an analyte of interest present in the sample, or a combination thereof. The analytical devices further include a nanochannel comprising a plurality of in-plane nanopores in series fluidically coupled to the sample processing region. The in-plane nanopores can be used to detect and/or analyze analyte(s) present in the sample following processing by the sample processing region. These analytical devices can advantageously provide for the label-free detection of single molecules.