The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2025

Filed:

Jul. 17, 2023
Applicants:

Trustees of Boston University, Boston, MA (US);

The General Hospital Corporation, Boston, MA (US);

Inventors:

Firas H. El-Khatib, Allston, MA (US);

Edward R. Damiano, Acton, MA (US);

Steven J. Russell, Lincoln, MA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61M 5/172 (2005.12); A61B 5/00 (2005.12); A61B 5/145 (2005.12); A61M 5/142 (2005.12);
U.S. Cl.
CPC ...
A61M 5/1723 (2012.12); A61B 5/14532 (2012.12); A61B 5/4839 (2012.12); A61M 2005/14208 (2012.12);
Abstract

A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon. An adaptation region with upper and lower bounds for the glucose target may be imposed. Generally the disclosed techniques can provide for robust and safe glucose level control. Adaptation may be based on computed doses of a counter-regulatory agent whether or not such agent is actually delivered to the subject, and may be used for example to adjust operation in a bihormonal system during periods in which the counter-regulatory agent is not available for delivery.


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